Does Ketamine Attenuate Depression of Respiratory and Cardiac Functions

Ibaraki Children's Hospital

Status: Completed

Conditions: Sedated for Cardiac Catheterization; Congenital Heart Disease

Treatments: Drug: Ket10; Drug: Ket20; Drug: control

Study type: Interventional

Funder types: Other

Identifiers

NCT01501786

ketamine in sedation

Details and patient eligibility

About

Normal cardiac and respiratory functions should be maintained during pediatric cardiac catheterization. Propofol has become a popular choice for sedation in children, however, it depresses cardiac and respiratory functions. Some investigators reported that ketamine attenuates its depressant effect, but it remains unclear whether ketamine reduces cardiac and respiratory depression caused by propofol in pediatric cardiac catheterization.

Enrollment: 150 patients

Sex: All

Ages: 6 months to 10 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 7kg-25kg (6mo-10yrs) children who undergo cardiac catheterization

Exclusion criteria

• patients who have neurological disease,
• endocrinological disease,
• airway anomaly, who require positive pressure ventilation

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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150 participants in 3 patient groups

control

Sham Comparator group

Description:

propofol and saline are administered

Treatment:

Drug: control

Ket10

Experimental group

Description:

ketamine is co-administered with propofol

Treatment:

Drug: Ket10

Ket20

Experimental group

Description:

ketamine is co-administered with porpofol

Treatment:

Drug: Ket20