Does Local Morphine Add to Local Anesthetics in Serratus Anterior Plane Block Has a System Analgesic Effect?

Fatma Adel El sherif,MD

Status: Completed

Conditions: Postoperative Complications

Treatments: Drug: Morphine Sulfate; Drug: Bupivacaine Hydrochloride

Study type: Interventional

Funder types: Other

Identifiers

NCT02962024

348

Details and patient eligibility

About

the investigators aim is to investigate and explore the effect 10 mg morphine added to local anesthetics in serratus anterior plane block for post mastectomy pain management after modified radical mastectomy in patients with breast cancer with assessment of its serum level if it will be absorbed systemically or not?

Enrollment: 40 patients

Sex: Female

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• (ASA) class I-II
• body weight of 50 - 90 kg

Exclusion criteria

• a history of bleeding diathesis,
• relevant drug allergy, opioid dependence,
• sepsis, prior surgery in the supraclavicular, infraclavicular or axillary regions, alcohol or drug abuse , patients with advanced cardiovascular disease

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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40 participants in 2 patient groups, including a placebo group

morphine sulphate

Active Comparator group

Description:

10mg locally morphine hydrochloride once betwwen serratus muscle and latissmus dorsi muscle

Treatment:

Drug: Morphine Sulfate

bupivacaine hydrochloride

Placebo Comparator group

Description:

0.25%locally bupivacaine hydrochloride once

Treatment:

Drug: Bupivacaine Hydrochloride