Does Low-Dose Aspirin Improve Outcome in In Vitro Fertilisation/Intra Cytoplasmatic Sperm Injection (IVF/ICSI)?

Ghent University Hospital (UZ)

Status and phase: Completed; Phase 3

Conditions: Infertility

Treatments: Drug: placebo; Drug: aspirin

Study type: Interventional

Funder types: Other

Identifiers

NCT00644085

99/191

Details and patient eligibility

About

To investigate the effect of daily administration of low-dose aspirin, compared to placebo, on IVF and ICSI outcome.

Enrollment: 201 patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

• Dutch-speaking women
• Starting a first or second IVF/ICSI cycle

Exclusion criteria

• Women suffering from

  • platelet dysfunction
  • thrombopenia
  • gastro-intestinal ulcers
  • recurrent gastritis
  • aspirin hypersensitivity

• Women on treatment with anticoagulants or aspirin

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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201 participants in 2 patient groups, including a placebo group

1

Experimental group

Description:

oral administration of aspirin 100 mg

Treatment:

Drug: aspirin

2

Placebo Comparator group

Description:

oral administration of placebo

Treatment:

Drug: placebo