Does Meal Timing Affect Energy Expenditure (GRAZING)

Pennington Biomedical Research Center

Status

Completed

Conditions

Meal Timing

Treatments

Behavioral: Grazing

Behavioral: Time-restricted feeding (early eating)

Study type

Interventional

Funder types

Other

Identifiers

NCT02247076

PBRC 2014-038

Details and patient eligibility

About

The purpose of this study is to find out if meal timing affects calories burned and blood sugar levels.

Full description

10 overweight adult men and women will eat according to two different eating schedules: grazing and time-restricting feeding ("early eating"). While on each eating schedule, metabolism (calories burned) will be measured during a 24-hour stay in a respiratory chamber. Glucose levels-as well as key diurnal rhythms such in heart rate-will also be measured continuously. This study requires two 1-week periods of participation.

Enrollment

11 patients

Sex

All

Ages

20 to 45 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Are 20-45 years of age
Have a weight between 150 and 220 lbs
Have a body mass index between 25 and 35 kg/m2 inclusive (a number calculated from your height and weight)
If you are a female, have a regular menstrual cycle that is between 25 and 35 days long
If you are female, had your period within the last 35 days
Regularly go to sleep between 9:30 pm and 12:00 am
Regularly eat dinner 9 or more hours after eating breakfast
Are willing to have about 2/3 cup of your blood stored for future research related to this study

Exclusion criteria

Have diabetes or are on anti-diabetes medication
Suffer from significant cardiovascular, renal (kidney), cardiac (heart), liver, lung or nervous system disease
Have stomach or intestinal problems
Regularly use medications such as steroids, beta blockers, adrenergic-stimulating agents, and laxatives
Take any medications or supplements known to affect sleep, circadian rhythms, or metabolism (with the exception that certain forms of birth control are allowed)
Have abnormal lab work that is clinically significant in the opinion of the study physician
Are pregnant or lactating
Take the Depo Provera shot, or use an Interuterine Device (IUD) or hormone patch for birth control
If you are on hormonal birth control, have been on a stable dose for less than 3 months
Have smoked or used nicotine/tobacco products within the last 3 months
Regularly do competitive sport training
Perform overnight shift work an average of one or more times per week
Have an irregular sleep schedule
Have an irregular eating schedule
Regularly drink 3 or more drinks of alcohol per day
Are not able or are unwilling to eat only the food and drink served to you by Pennington Biomedical, while in the study
Are not able or are unwilling to refrain from strenuous exercise while participating in the study
Are not able to spend 2 separate full days (for about 25 hours each) at Pennington Biomedical
Are not able to maintain a consistent sleep schedule while participating in the study
Are not able to maintain a consistent eating schedule while participating in the study
Are not able to stop drinking coffee and other caffeine-containing drinks on the day of and day prior to testing