Does Perineural Dexamethasone Prolong Duration of a Nerve Block?

Rigshospitalet

Status and phase: Completed; Phase 2

Conditions: Healthy Volunteers

Treatments: Drug: Ropivacaine + placebo; Drug: Ropivacaine + dexamethasone

Study type: Interventional

Funder types: Other

Identifiers

NCT02351804

2014-004879-23 (EudraCT Number)

SM2-PJ-14

Details and patient eligibility

About

The purpose of this study is to investigate whether dexamethasone as an adjuvant to ropivacaine for adductor canal block increases duration of the sensory block, when controlling for a systemic effect using a paired design and bilateral blocks.

The investigators hypothesize that adding dexamethasone to ropivacaine will prolong block duration compared with ropivacaine + placebo.

Enrollment: 20 patients

Sex: Male

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists class 1
• Body Mass Index 18-30

Exclusion criteria

• Allergy to study medication
• Earlier trauma or surgery to lower limb
• Diabetes Mellitus
• Alcohol or drug abuse
• Daily intake of opioids or steroids last 4 weeks
• Daily intake of any analgesics last 48 hours

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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20 participants in 2 patient groups, including a placebo group

Ropivacaine + dexamethasone

Experimental group

Description:

20 ml ropivacaine 0.5% + 0.5 ml dexamethasone 4 mg7ml

Treatment:

Drug: Ropivacaine + dexamethasone

Ropivacaine + placebo

Placebo Comparator group

Description:

20 ml ropivacaine 0.5% + 0.5 ml isotonic saline ad

Treatment:

Drug: Ropivacaine + placebo