Does Positive Pressure Extubation Reduce Postoperative Desaturation? (EXTUBPOS)

University Hospital, Lille

Status: Enrolling

Conditions: Postoperative Complications; Lung Ultrasound Score; Extubation

Treatments: Procedure: positive pressure during extubation procedure

Study type: Interventional

Funder types: Other

Identifiers

NCT05295095

2021_0433

2021-A03064-37 (Other Identifier)

Details and patient eligibility

About

Single-center, prospective, controlled, parallel, randomized, single-blind study comparing the conventional extubation technique to two positive pressure extubation techniques on postoperative desaturations

Full description

Study realise on university hospital on Lille in France. Patients inclusion is prospective and randomised in three groups. First group : extubation is realised with aspiration in tracheal tube during removal tube Second group : extubation is realised without aspiration but with APL valve set to 20cmH20 Third group : extubation is realised without aspiration but with ventilator parameters were set for PSV mode (inspiratory pressure of 10cmH2O and PEEP identical to that administered in the operating room

Enrollment: 264 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Visceral or urological surgery
• Scheduled surgery
• Surgical or patient requirement: placement of an arterial catheter
• Supine position
• Post-surgical extubation scheduled in the operating room
• Minimum age of 18 years
• Informed and signed consent

Exclusion criteria

• Severe obesity (BMI over 35kg/m2)
• pregnant woman
• Acute or chronic preoperative respiratory pathology.
• Sleep apnea syndrome
• Inability to receive informed information (does not speak, read or understand French)
• Patient under guardianship or curatorship
• Lack of social security coverage
• History of intubation or criteria for difficult intubation or ventilation.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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264 participants in 3 patient groups

control group

No Intervention group

Description:

Classical extubation technique : ETT was removed with continuous endotracheal suction

VSPEP

Experimental group

Description:

ETT was removed with APL valve set to 20cmH2O

Treatment:

Procedure: positive pressure during extubation procedure

VSAIPEP

Experimental group

Description:

ETT removed with ventilator parameters were set for PSV mode (inspiratory pressure of 10cmH2O and PEEP identical to that administered in the operating room

Treatment:

Procedure: positive pressure during extubation procedure