Does Preconditioning Affects Other Organs in Patients Undergoing Open Heart Surgery ?

Assiut University

Status: Completed

Conditions: Mechanical Ventilation; Neutrophil Lymphocyte Ratio; Serum Createnine

Treatments: Drug: Pharmacologic preconditionig; Procedure: ischemic preconditioning

Study type: Interventional

Funder types: Other

Identifiers

NCT03097692

IRB00009909

Details and patient eligibility

About

An association between white blood cell count (WBC), neutrophil-lymphocyte ratio , and inflammatory process is well known . Ischemic preconditioning reduces the inflammation

Full description

Preliminary evidence has suggested the role of inflammation in development and prognosis of cardiovascular diseases and cancers. Most of the prognostic studies failed to account for the effects of co-morbid conditions as these might have raised the systemic inflammation. We used neutrophil lymphocyte ratio (NLR) as a measure of systemic inflammation and investigated its association with cardiac preconditioning in open heart surgery .

Enrollment: 100 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• 18-60 years old
• American Society of Anesthesiologists physical status II and III
• Patients scheduled for open heart surgery
• no active inflammatory process

Exclusion Criteria:Exclusion Criteria:

• Emergency surgery
• Clinically significant kidney or liver disease
• Patients allergic to local anesthetic
• Patients with prolonged cardiopulmonary bypass time (>120 min)
• Patients required intra-aortic balloon pump
• Postoperative hemodynamic instability (including the occurrence of serious arrhythmia) or bleeding that required surgical re-exploration

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

100 participants in 2 patient groups

Ischemic preconditioing

Active Comparator group

Description:

50 patients ischemic preconditioning will be done after induction and before cardiopulmonary bypass by inflation the cuff of blood pressure above 200mmhg in the lower limb every 5 min for 3cycles

Treatment:

Procedure: ischemic preconditioning

Pharmacologic preconditioing

Active Comparator group

Description:

by sevoflurane anesthesia

Treatment:

Drug: Pharmacologic preconditionig