Does Sedation Depth (as Evaluated by the Bispectral Index) Influence Dynamic Indices of Preload Dependence? (BIS2)

Centre Hospitalier Universitaire, Amiens

Status: Completed

Conditions: Thoracic Surgery

Treatments: Device: transthoracic echocardiography

Study type: Observational

Funder types: Other

Identifiers

NCT02812758

PI2015_843_0012

Details and patient eligibility

About

Dynamic indices of preload dependence (such as stroke volume variability -SVV , pulse pressure variability - PPV and plethysmograph variability index - PVI ) are reportedly predictive of the response to vascular filling in sedated, mechanically ventilated patients. However, the influence of the sedation depth on these dynamic indices has never been evaluated.

Enrollment: 45 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All sedated, intubated, mechanically ventilated adult (over-18) patients admitted for elective cardiac surgery, monitored for sedation depth (with the BIS) and for preload dependence indices (SVV, PPV and PVI)
• Good echogenicity
• Social security coverage

Exclusion criteria

• Pregnancy, legal guardianship
• Subjects with black skin (a known technical limitation of plethysmography)
• Cardiac arrhythmia
• Sepsis
• Poor echogenicity

Trial design

45 participants in 1 patient group

patients

Description:

All sedated, intubated, mechanically ventilated adult patients admitted for elective cardiac surgery, monitored for sedation depth (with the BIS) and for preload dependence indices (SVV, PPV and PVI) transthoracic echocardiography

Treatment:

Device: transthoracic echocardiography