ClinicalTrials.Veeva

Menu

Does Sedation Depth (as Evaluated by the Bispectral Index) Influence Dynamic Indices of Preload Dependence? (BIS2)

C

Centre Hospitalier Universitaire, Amiens

Status

Completed

Conditions

Thoracic Surgery

Treatments

Device: transthoracic echocardiography

Study type

Observational

Funder types

Other

Identifiers

NCT02812758
PI2015_843_0012

Details and patient eligibility

About

Dynamic indices of preload dependence (such as stroke volume variability -SVV , pulse pressure variability - PPV and plethysmograph variability index - PVI ) are reportedly predictive of the response to vascular filling in sedated, mechanically ventilated patients. However, the influence of the sedation depth on these dynamic indices has never been evaluated.

Enrollment

45 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • All sedated, intubated, mechanically ventilated adult (over-18) patients admitted for elective cardiac surgery, monitored for sedation depth (with the BIS) and for preload dependence indices (SVV, PPV and PVI)
  • Good echogenicity
  • Social security coverage

Exclusion criteria

  • Pregnancy, legal guardianship
  • Subjects with black skin (a known technical limitation of plethysmography)
  • Cardiac arrhythmia
  • Sepsis
  • Poor echogenicity

Trial design

45 participants in 1 patient group

patients
Description:
All sedated, intubated, mechanically ventilated adult patients admitted for elective cardiac surgery, monitored for sedation depth (with the BIS) and for preload dependence indices (SVV, PPV and PVI) transthoracic echocardiography
Treatment:
Device: transthoracic echocardiography

Trial contacts and locations

1

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2025 Veeva Systems