Does Serum Procalcitonin Levels Predict Sepsis in Patients Undergoing Cytoreductive Surgery

Eastern Regional Medical Center

Status: Completed

Conditions: Cytoreductive Surgery

Treatments: Other: Serum procalcitonin lab draws

Study type: Observational

Funder types: Other

Identifiers

NCT02189434

ERMC 14-14

Details and patient eligibility

About

Serum procalcitonin levels will be considerably higher, for a longer period of time, in patients who develop sepsis compared to patients with SIRS or those who have an uncomplicated post-surgical recovery. Monitoring of serum procalcitonin trends will allow for an earlier diagnosis of, and initiation of treatment for, sepsis compared to current standard ICU methods.

Enrollment: 20 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Female or male person ≥ 18 years of age
• Biopsy proven carcinoma
• Scheduled for cytoreductive surgery, with or without HIPEC
• Eastern Cooperative Oncology Group (ECOG) performance status (PS) = 0, 1, or 2
• Able to give informed consent for protocol participation

Exclusion criteria

• Participants are not able to understand or provide written informed consent
• Pre-operative anti-inflammatory medication use within 72 hours of their baseline blood draw
• Pre-operative infection treatment with corticosteroids within 72 hours of their baseline blood draw
• Immunosuppressive illness other than neoplasm
• Pregnant or lactating female

Trial design

20 participants in 1 patient group

Cytoreductive surgery

Description:

Patients having undergone cytoreductive surgery with or without HIPEC will have serum procalcitonin lab draws

Treatment:

Other: Serum procalcitonin lab draws