Does the Air-bubble Location Influence on the Implantation Rate (TRANSFER)

IVI Vigo

Status

Completed

Conditions

Embryo Disorder

Treatments

Other: Collect retrospectively data on embryo implantation rate

Study type

Observational

Funder types

Other

Identifiers

NCT04574310

1607-VGO-056-EM

Details and patient eligibility

About

The main objective of the study is to evaluate whether there is any association between the location into the uterine cavity, where the air bubbles containing the pre-embryos were placed, and the implantation rate. Therefore, the images generated during pre-embryos transfer are available in our database and studied retrospectively.

Full description

The success of a reproductive treatment is determined by three variables: the pre-embryo quality, endometrial receptiveness and pre-embryo transfer. Several previous studies show a lack of agreement concerning the greatest measurement. For instance, some of them refer to the distance between the catheter and the uterine fundus, whereas some others take as a reference the air-bubble where the pre-embryos were placed.

It is for this reason that in the present study, we aim to evaluate the air bubble location ratio into the uterine cavity with reproductive success, taking into account the different variables to reach success. That is, embryo characteristics (quality, development day) endometrium preparation (cycle type, hormone levels on day 5) and even the transfer procedure (type of catheter, blood, difficulty channeling).

It is a study that aims to collect data from January 2013 to october 2019. To this end, the images generated during pre-embryos transfer are analyzed retrospectively. Therefore, it is evaluated the existing differences on implantation rate according to air-bubble placement into uterine cavity during the transfer procedure.

Enrollment

400 patients

Sex

Female

Ages

30 to 50 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients with normal uterine anatomy, who underwent an ultrasound guided embryo transfer.
BMI< 30kg/m2.
Ultrasound guided embryo transfer made by the same researcher.

Exclusion criteria

Presence of uterine fibroid in the anterior uterine body that make difficult the transfer visualization.
Asherman Syndrome.
Adenomyosis that reduces the uterine cavity visibility.
Difficult transfers where the use of a semi-rigid cannula sheath is needed to entry into the uterine cavity.
Previous uterine surgery that alters its anatomy.
Istmocele