Does the Embryo Transfer Technique Affect the Success of in Vitro Fertilization?

Acibadem Kadiköy Hospital

Status: Unknown

Conditions: IVF; Infertility; Assisted Reproductive Technology

Treatments: Procedure: Trial followed by transfer; Procedure: Afterload Transfer

Study type: Interventional

Funder types: Other

Identifiers

NCT03756857

AcibademKD

Details and patient eligibility

About

Prospective, open, randomized, parallel, two-arm trial to compare the clinical pregnancy rate between most commonly used two embryo transfer techniques: trial followed by transfer technique and afterloading technique

Full description

Eligible patients will be informed about the possibility of participating in the clinical trial in the beginning of treatment and on the day ET, a signed consent form will be collected from those recipients who confirmed their participation. These patients will be randomized immediately before the ET procedure by sequentially numbered, opaque, sealed envelopes

Enrollment: 200 estimated patients

Sex: Female

Ages: 20 to 37 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Patient has given written informed consent
2. BMI 18-30 kg/m2
3. < 2 previous failed IVF trials
4. At least two good quality embryos on the day of transfer

Exclusion criteria

1. Congenital uterine anomaly
2. Untreated endometrial polyp or fibroid distorting uterine cavity
3. Presence of hydrosalpinx 4.2 or more prior IVF trial failure

5.Moderate to severe endometriosis 6.Recurrent pregnancy loss history

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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200 participants in 2 patient groups

Afterload transfer

Experimental group

Description:

First, an empty catheter passes to the level of the lower uterine segment under ultrasound guidance to a point where the inner catheter enters the endometrial cavity. The inner sheath is removed slowly, leaving the outer sheath just beyond the internal os. After verifying the catheter's position on the TA ultrasound scan, the physician gives the signal to the embryologist to start the embryo loading. The embryologist brings the loaded inner catheter and inserts it into the outer sheath, which is maintained in its position by the physician.

Treatment:

Procedure: Afterload Transfer

Trial Followed by Transfer

Experimental group

Description:

First a trial transfer is performed using both the inner catheter and outer sheath connected together in standard configuration, just before the actual embryo transfer. It is passed up to and just through the the internal os. When it appears that the actual transfer will be possible without great difficulty ,the trial catheter is withdrawn. An embryo transfer catheter is loaded and the actual transfer is performed

Treatment:

Procedure: Trial followed by transfer