Does the Natural Medicinal Plant St John's Wort Affect the Glucose Tolerance in Healthy Individuals

University of Southern Denmark (SDU)

Status and phase: Completed; Phase 1

Conditions: Type 2 Diabetes

Treatments: Other: St John's wort

Study type: Interventional

Funder types: Other

Identifiers

NCT01921881

AKF-385

Details and patient eligibility

About

The goal of the study is to examine if healthy individuals that ingest St John's wort will have a significantly difference in glucose tolerance.

Enrollment: 10 patients

Sex: Male

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18-40 years
• Males
• Fasting plasma-glucose < 7.0 mmol/L
• Glycosylated haemoglobin A1c within reference or clinically insignificant deviation hereof
• Body mass index < 30 kg/m^2

Exclusion criteria

• Hypersensitivity to St John's wort
• Chronical or daily alcohol abuse
• Known liver disease
• Ingestion of drugs requiring prescription, except locally acting drugs

Trial design

10 participants in 1 patient group

St John's wort

Experimental group

Description:

Subjects will undergo 3 oral glucose tolerance tests: 1. Without taking any St John's wort 2. After 3 weeks pretreatment with St John's wort 3. Minimum 6 weeks after last St John's wort ingestion

Treatment:

Other: St John's wort