Does the Use of a Videolaryngoscope Modifies Anesthetic Induction ? (MGM-PicRemi)

Hopital Foch

Status: Completed

Conditions: Tracheal Intubation

Treatments: Procedure: Tracheal intubation; Drug: Propofol and remifentanil anesthesia

Study type: Interventional

Funder types: Other

Identifiers

NCT02245789

2013-A01308-37 (Other Identifier)

2013/43

Details and patient eligibility

About

Videolaryngoscopes become widely used. The aim of this study is to compare anesthetic induction when patients are tracheally intubated using a MacGraph Mac videolaryngoscope or a conventional MacIntosh laryngoscope.

Tracheal intubation induces a nociceptive stimulation. Hypothesis is that the use of a videolaryngoscope induces a less pronounced nociceptive stimulation and, consequently, that it modifies the anesthetic drugs requirement. .

Full description

All patients will received a standardized anesthetic procedure : combined closed-loop anesthesia system using bispectral index as control variable and two proportional-differential control algorithms, a propofol and a remifentanil target-controlled infusion system. The effectiveness of such a closed-loop anesthesia system has been demonstrated in a prospective, randomized study.

Patients will be randomized in two groups : intubation using a conventional MacIntosh laryngoscope or intubation using a videolaryngoscope.

If our hypothesis is confirmed, the required concentration of remifentanil, an opioid agent, will be reduced in the group using a videolaryngoscope.

Enrollment: 50 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patient scheduled for a general anesthesia with orotracheal intubation

Exclusion criteria

• predictable risk of difficult mask ventilation or of difficult tracheal intubation
• necessity of a rapid sequence induction
• contra-indication to the use of the automated administration of propofol and of remifentanil
• contra-indication to the use of atracurium
• Otolaryngology, thoracic surgery, or intracranial surgery

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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50 participants in 2 patient groups

Macintosh laryngoscope

Active Comparator group

Description:

Tracheal intubation will be performed using a Macintosh laryngoscope. All patients will received propofol and remifentanil anesthesia.

Treatment:

Drug: Propofol and remifentanil anesthesia

Procedure: Tracheal intubation

McGrath Mac videolaryngoscope

Experimental group

Description:

Tracheal intubation will be performed using a McGrath Mac videolaryngoscope. All patients will received propofol and remifentanil anesthesia.

Treatment:

Drug: Propofol and remifentanil anesthesia

Procedure: Tracheal intubation