Does Valproate Increase Levels of Folate Receptor Autoantibodies in Women?
Status
Completed
Conditions
Epilepsy
Psychiatric or Mood Diseases or Conditions
Treatments
Other: No intervention
Details and patient eligibility
About
Women who take folate (folic acid) before getting pregnant can lower the risk of giving birth to infant with certain birth defects. However, some medications may affect the action of folate. The purpose of this study is to compare the effect of two anti-epileptic drugs on how folate works in our body.
Enrollment
38 patients
Sex
Female
Ages
18 to 50 years old
Volunteers
No Healthy Volunteers
Inclusion criteria
- Women ages 18-50 years inclusive who are taking valproate or lamotrigine for neurologic or psychiatric conditions
- Valproate of lamotrigine must be used as monotherapy at stable doses for 6 weeks prior to the study for the neurologic or psychiatric illness; medications taken for other reasons are not excluded.
Exclusion criteria
- Women with prior exposure to valproate or lamotrigine if they are taking lamotrigine or valproate respectively.
Trial design
38 participants in 2 patient groups
Lamotrigine
Description:
No intervention
Treatment:
Other: No intervention
Valproate
Description:
No intervention
Treatment:
Other: No intervention
Trial contacts and locations
1
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Data sourced from clinicaltrials.gov
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