Domain-general and Domain-specific Contributions to the Development of Numerical Cognition (CFDDCN)

Centre Hospitalier St Anne

Status: Completed

Conditions: No Condition

Treatments: Other: cognitive tasks

Study type: Interventional

Funder types: Other

Identifiers

NCT06658392

D20-P011

Details and patient eligibility

About

Exploring the non-symbolic and symbolic arithmetic competencies in two groups of children (5-, and 7-year-olds). Additionally, we explored the relationship with domain-general factors such as inhibition and attention. Recorded fMRI.

Full description

Using T2*-weighted eip imaging, we measured BOLD response in two cohorts of healthy children while they were doing different cognitive tasks in the scanner. These tasks included solving non-symbolic (i.e. sets of elements) and symbolic (i.e. Arabic digits) addition and subtraction problems, a color control task, an attentional task measuring different facets of spatial attention, and a task measuring inhibition. We also recorded a high-resolution anatomical scan of the brain.

Enrollment: 58 patients

Sex: All

Ages: 5 to 7 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• school enrollment
• French as mother tongue
• right-handed
• normal medical, neurological and neuroradiological examinations - parents affiliated to a social security scheme

Exclusion criteria

• not within age range
• monocygotic twins
• • contraindications to an MRI examination (neurosensory stimulator or implantable defibrillator, cochlear implants, ferromagnetic ocular or cerebral foreign bodies close to nerve structures, metal prostheses, patient agitation: uncooperative or agitated patients, claustrophobic subjects, ventriculoperitoneal neurosurgical shunt valves, dental apparatus, etc.).
• sudden onset of cognitive problems that could indicate a stroke; a history of head trauma with loss of consciousness lasting more than 1 hour, or encephalitis; - a chronic neurological, psychiatric, endocrine, hepatic or infectious condition
• a history of major illness (diabetes, chronic lung disease, severe cardiac, metabolic, hematological, endocrinological or immunological disorders, cancer); - medication likely to interfere with brain imaging measurements
• color blindness or uncorrected visual disorders
• inability to take part in the study for geographical or psychiatric reasons
• presence of pervasive developmental and/or acquisition disorders identified by parents or legal guardians and/or teachers
• cerebral palsy
• impaired fine motor skills
• parents or legal guardians not affiliated to a social security scheme
• unaccompanied by parent(s) or legal guardian(s) during visits.
• tattoo not compatible with MRI
• children and parents under legal protection

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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58 participants in 1 patient group

arithmetic

Experimental group

Description:

exploring neurocognitive mechanisms underlying development of arithmetic competencies in healthy children.

Treatment:

Other: cognitive tasks