Donor and Recipient Mismatch in Liver Transplantation (DR-MM in LT)

University of Jena

Status: Completed

Conditions: Patient Survival; Liver Disease (Alcoholic or Not); Liver Transplant Surgery; Graft Survival

Study type: Observational

Funder types: Other

Identifiers

NCT07250919

20-5877.4

Details and patient eligibility

About

This observational study aims to investigate the impact of gender disparity between donors and recipients on long-term outcomes after liver transplantation. The study aims to answer the following question:

Does gender mismatch lower the possibility of survival after liver transplantation? Participants demonstrate gender dicrepancies between donors and recipients as regular concept in LT. The retrospective cohort study investigates the impact over a long-term follow up of 10 years.

Full description

The study involves patients who undergo liver transplantation at the Ajmera Transplant Centre Toronto from 2014 until 2022. The observation period ended at the first January 2025 to provide a minimal follow up of 24 months.

Liver transplant recipients with gender mismatch (A) will be compared with liver transplant recipients without gender mismatch (B).

Liver transplantation is the only curative treatment for people with end stage liver disease. Gender mismatch between donor and recipient, particularly, the combination of a female donor to male recipient has been controversial in the past. Identifying risk factors that could affect the survival of the graft and recipient is of the utmost importance.

Enrollment: 1,146 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients over the age of 18

Exclusion criteria

• Cases of retransplantation
• Combined organ transplantation
• Cases with >30% of missing values

Trial design

1,146 participants in 2 patient groups

GM +

Description:

Liver transplant recipients with gender mismatch

GM -

Description:

Liver transplant recipients without gender mismatch