Donor Circadian Rhythm and Its Correlation With Prognosis After Heart Transplantation (CIRCA-HTx)

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Status: Completed

Conditions: Circadian Rhythm; End-stage Heart Failure; Heart Transplantation

Study type: Observational

Funder types: Other

Identifiers

NCT07301788

2023-0291

JCZRYB202500142 (Other Grant/Funding Number)

82470423 (Other Grant/Funding Number)

2021YFA1101900 (Other Grant/Funding Number)

Details and patient eligibility

About

The goal of this observational study is to learn about the impact of donor heart procurement time based on circadian rhythm on the long-term outcomes of heart transplant recipients. The main question it aims to answer is:

Does the time of day when a donor heart is procured-specifically during the circadian repression phase (00:00-12:00) versus the activation phase (12:00-00:00)-affect post-transplant survival and rejection rates in patients with end-stage heart failure?

Patients undergoing heart transplantation at the study hospital will have leftover donor heart tissue and preservation fluid collected during surgery for multi-omics analysis. These participants will then be followed prospectively for up to three years to track survival and rejection outcomes.

Enrollment: 200 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patients undergoing heart transplantation surgery at our hospital due to end-stage heart failure.

Exclusion criteria

• Exclude patients undergoing multi-organ combined transplantation, re-do heart transplantation, or those with a history of other organ transplantation.