Dopamine Versus Norepinephrine Under General Anesthesia

Fudan University logo

Fudan University

Status and phase

Completed
Phase 3

Conditions

Hemodynamic Instability
Infant
Congenital Heart Disease
Anesthesia

Treatments

Drug: dopamine
Drug: norepinephrine

Study type

Interventional

Funder types

Other

Identifiers

NCT04536194
mzk-0003-2020

Details and patient eligibility

About

Participants under general anesthesia will be randomly treated with an adjusted dose dopamine or norepinephrine to elevate 10% of mean arterial pressure. Systemic hemodynamic data is recorded by PRAM and the change of cardiac index is compared between groups.

Full description

After intubation under general anesthesia, radial arterial is cannulated and pressure transducer is connected to MostCare(core technique PRAM). CI, SVRI, SVI, SVV, dp/dt and HR are recorded before and after a infusion of dopamine or norepinephrine to elevate 10% of mean arterial pressure. Changes of these hemodynamic data are compared.

Enrollment

60 patients

Sex

All

Ages

1 to 12 months old

Volunteers

No Healthy Volunteers

Inclusion criteria

* undertake cardiac surgery for congenital heart disease

Exclusion criteria

* Aortic valve or aortic disease * severe arrhythmia * use of cardiovascular active drugs before anesthesia * need to use a combination of different cardiovascular support drugs after anesthesia

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

60 participants in 2 patient groups

norepinephrine
Experimental group
Description:
infusion of norepinephrine with a adjusted dose to elevate 10% of mean arterial pressure
Treatment:
Drug: norepinephrine
Dopamine
Active Comparator group
Description:
infusion of dopamine with a adjusted dose to elevate 10% of mean arterial pressure
Treatment:
Drug: dopamine

Trial contacts and locations

1

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2024 Veeva Systems