Doppler at the Diagnosis in Predicting Perinatal Outcomes in Early and Late-onset Fetal Growth Restriction

Central Hospital, Nancy, France

Status: Completed

Conditions: Fetal Growth Retardation

Treatments: Other: Ultrasound

Study type: Observational

Funder types: Other

Identifiers

NCT05696223

2022PI187-343

Details and patient eligibility

About

When a FGR is diagnose, the challenge in his monitoring is to assess the benefit-risk balance between continuing the pregnancy in order to limit complications related to prematurity and birth in order to minimize any risk of fetal death in utero. By able to know the characteristics of fetal deteriorations and its relationship with fetal and neonatal outcomes could be a thankful help in this decision. The placental insufficiency is by far the most common cause of FGR (32)(miller 2008). This effect can be documented thanks to ultrasound examinations to study fetal growth and Doppler of umbilical arteries for the placenta, the middle cerebral artery for the brain perfusion and the Ductus Venosus for the cardiac effects of placental dysfunction. The apparition of Doppler abnormalities suggests a deterioration of the disease and leads to several changes in clinical FGR management. Nevertheless, at this time, very few studies allow us to predict the time util the degradation and their impact on perinatal outcomes.

The primary aim of this study was to evaluate the performance of the Doppler at the time of diagnosis in predicting the outcome of pregnancies. The secondary aim was to evaluate the performance of Doppler performed at any time during pregnancy and studied independently in predicting outcome of pregnancies

Enrollment: 220 patients

Sex: Female

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Fetal growth restriction of antenatal diagnosis

Exclusion criteria

• Twin pregnancies, non-isolated IUGR, post-natal diagnosis of FGR and incomplete records

Trial design

220 participants in 2 patient groups

Early fetal growth restriction

Description:

Fetal growth restriction diagnosed before 32 SA

Treatment:

Other: Ultrasound

Late fetal growth restriction

Description:

Fetal growth restriction diagnosed after 32 SA

Treatment:

Other: Ultrasound