Doppler Sonography, MR Venography, Plethysmography for the Diagnosis of CCSVI

Euromedic Specialist Clinics, Poland

Status: Completed

Conditions: Chronic Cerebrospinal Venous Insufficiency

Treatments: Other: Catheter venography of internal jugular veins; Other: Magnetic resonance venography of internal jugular veins; Other: Doppler sonography of internal jugular veins; Other: Air-plethysmography of the neck

Study type: Interventional

Funder types: Other

Identifiers

NCT01425554

20/2011

Details and patient eligibility

About

This study is aimed at evaluation of diagnostic value of Doppler sonography, MR venography and air-plethysmography for the assessment of abnormalities in the internal jugular veins, with catheter venography as the reference test.

Enrollment: 126 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

1. Patients group

   Inclusion Criteria:

   • confirmed diagnosis of multiple sclerosis

   Exclusion Criteria:

   • coexisting another neurologic pathology (e.g. stroke, Parkinson disease)
   • significant stenosis of carotid or vertebral arteries
   • other significant abnormalities of blood vessels of the upper part of the body
   • tricuspid valve incompetence
   • allergy to iodine contrast dye
   • chronic renal failure
   • pregnancy
   • other severe comorbidities or significant abnormalities in standard lab tests

2. Healthy volunteers.

Inclusion Criteria:

• none

Exclusion Criteria:

• confirmed diagnosis of multiple sclerosis or related pathologies (CIS, NMO)
• coexisting another neurologic pathology (e.g. stroke, Parkinson disease)
• significant stenosis of carotid or vertebral arteries
• other significant abnormalities of blood vessels of the upper part of the body
• tricuspid valve incompetence

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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126 participants in 1 patient group

Diagnostic study

No Intervention group

Treatment:

Other: Catheter venography of internal jugular veins

Other: Air-plethysmography of the neck

Other: Magnetic resonance venography of internal jugular veins

Other: Doppler sonography of internal jugular veins