Doppler Ultrasound Assisted Varicocelectomy Improve Sperm Qualities

The Second Hospital of Shandong University

Status: Unknown

Conditions: Varicocele

Treatments: Procedure: Laparoscopic varicocelectomy; Procedure: Microscopic Subinguinal varicocelectomy

Study type: Interventional

Funder types: Other

Identifiers

NCT02695199

49557309-6

Details and patient eligibility

About

To evaluate the benefits of laparoscopic Doppler ultrasound (LDU) assisted laparoscopic varicocelectomy (LV) and compare the surgical outcomes and complications between LDU assisted LV (LDU-LV) and microscopic subinguinal varicocelectomy for infertile patients with varicoceles.

Full description

To compare the surgical outcomes such as semen parameters and the pregnancy rate and complications like postoperative varicocele recurrence and hydrocele between laparoscopic Doppler ultrasound assisted laparoscopic varicocelectomy and conventional microscopic subinguinal for infertile patients with varicoceles. To examine the microanatomy of the spermatic cord within suprainguinal portion.

Enrollment: 100 estimated patients

Sex: Male

Ages: 20 to 39 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. 20-39 years old who had infertility for more than 1 year and had clinical palpable varicoceles;
2. impaired semen quality including sperm concentration <15 million/ml or total motility <40% or progressively motile < 32% (a+b), the 5th edited World Health Organization criteria was referred;
3. with normal level of serum hormones including follicle stimulating hormone, luteinizing hormone, Thyroid hormones and prolactin;
4. patient's spouse was healthy in reproduction.

Exclusion criteria

1. with subclinical varicocele, recurrent varicoceles;
2. normal semen analyses;
3. other reasons of infertility than varicoceles;
4. refusing to enter randomization;
5. female partner older than 35 years;
6. with abnormal level of serum hormones;
7. female factor infertility;
8. with significant surgical diseases, congenital diseases or endocrine diseases.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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100 participants in 2 patient groups

laparoscopic varicocelectomy

Experimental group

Description:

laparoscopic Doppler ultrasound assisted laparoscopic varicocelectomy group

Treatment:

Procedure: Laparoscopic varicocelectomy

microscopic varicocelectomy

Sham Comparator group

Description:

conventional Microscopic Subinguinal varicocelectomy group

Treatment:

Procedure: Microscopic Subinguinal varicocelectomy