Dose-Dependent Effects of Erythritol on Endothelial Function in Type 2 Diabetes Mellitus

Boston University

Status

Completed

Conditions

Type 2 Diabetes Mellitus

Treatments

Dietary Supplement: Erythritol

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT01908348

H-32353

Details and patient eligibility

About

This study is an open-label pilot designed to examine the dose-dependent effects of erythritol, a zero calorie sweetener, on endothelial function. Twenty-four subjects with type 2 diabetes mellitus will make three study visits. At each visit, the will consume an orange-flavored beverage containing escalating amounts of erythritol (6, 12, and 18 grams). Endothelial function will be assessed before and two hours after beverage consumption. Endothelial function will be measured as the change in pulse amplitude in response to reactive hyperemia measured in the fingertip by peripheral arterial tonometry. The results will be used to plan a randomized, placebo-controlled study.

Enrollment

27 patients

Sex

All

Ages

35 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Male and Female subjects
Otherwise healthy patients with Type 2 diabetes mellitus as defined by fasting blood glucose >125 mg/dl or with ongoing treatment for Type 2 diabetes mellitus with the exception of insulin.

Exclusion criteria

Women with a positive urine pregnancy test
Body mass index >35 kg/m2
Current daily long-acting insulin therapy (short acting, insulin as needed is not an exclusion).
Clinical history of other major illness including cancer, renal failure, hepatic failure, or other conditions that in the judgment of the principal investigator make a clinical study inappropriate.
Treatment with an investigational drug within the last twelve weeks
History of a psychological illness or condition such as to interfere with the subject's ability to understand the requirements of the study.
Treatment with vitamin E, vitamin C, and beta carotene, lipoic acid, and other food or herbal supplements within 1 month of enrollment. Subjects taking multivitamins or other forms of vitamin E and C in doses that do not exceed two times the recommended daily allowance will not be excluded.
Recent change in diet or level of physical activity that in the judgment of the investigators would be likely to affect endothelial function (to be evaluated on a case by case basis).
Ongoing illicit drug use or alcohol abuse.
Sensitivity/intolerance to dietary polyols.