Dose-dependent Effects of Second-hand Smoke on Vascular Function
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Details and patient eligibility
About
The purpose of this study is to determine the vascular effects of brief second-hand smoke exposure on normal healthy individuals.
Full description
Second-hand smoke remains a significant public health threat. Despite evidence to suggest that secondhand smoke contributes to adverse cardiovascular outcomes, little is known about the dose-dependent vascular effects of brief secondhand smoke exposure at low doses commonly encountered in the community. This study will investigate the acute vascular effects and dose-dependent biological mechanisms of secondhand smoke on endothelial function and oxidative stress.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Healthy non-smoking adults
Exclusion criteria
- Reported Active Smoking
- History of diabetes, hypertension, chronic respiratory disease, coronary artery disease, prior myocardial infarction or heart failure
- Pregnancy or breastfeeding
- Current use of prescription drugs within 14 days of trial
- Reported significant passive smoke exposure or elevated cotinine levels
Trial design
Primary purpose
Allocation
Interventional model
Masking
33 participants in 3 patient groups, including a placebo group
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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