Dose Efficiency of Modern CT Scanners in Oncologic Scans

University Hospital Augsburg

Status: Unknown

Conditions: Metastatic Cancer; Neoplasms; Neoplasm Metastasis

Treatments: Diagnostic Test: Scan at CT scanner 3; Diagnostic Test: Scan at CT scanner 1; Diagnostic Test: Scan at CT scanner 2

Study type: Interventional

Funder types: Other

Identifiers

NCT04989192

21-0280

Details and patient eligibility

About

CT-Staging is crucial for therapy planning of patients with malignancies. Dose efficiency and image quality are important parameters for these examinations. Up to now, scientific evidence of dose efficiency of modern CT scanners is mostly derived from retrospective analyses. This prospective study systematically analyzes dose efficiency and image quality of three modern CT scanners by randomization of patients who are scheduled for a CT scan to examine the status of malignancies. After giving informed consent and randomization (1:1:1), the CT scan will be performed at one of the modern CT scanners available at our department. This will allow a systematic allocation to the different scanners.

Enrollment: 2,400 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• clinical suspicion of a malignancy or known / confirmed malignancy AND
• indication for contrast-enhanced CT of the body confirmed by board-certified radiologist ('justifying indication' according to German/European radiation protection law) AND
• patient (is able to give informed consent and) has given informed consent.

Exclusion criteria

• age < 18 years
• known or suspected pregnancy
• contraindications for contrast agent (renal failure, allergy, hyperthyroidism)

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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2,400 participants in 3 patient groups

CT scanner 1

Other group

Description:

Patients will undergo imaging on scanner 1.

Treatment:

Diagnostic Test: Scan at CT scanner 1

CT scanner 2

Other group

Description:

Patients will undergo imaging on scanner 2.

Treatment:

Diagnostic Test: Scan at CT scanner 2

CT scanner 3

Other group

Description:

Patients will undergo imaging on scanner 3.

Treatment:

Diagnostic Test: Scan at CT scanner 3