Dose for Deep Neuromuscular Blockade Deciding Factor of Neuromuscular Blocker Dose for Deep Neuromuscular Blockade

Seoul National University

Status: Unknown

Conditions: Laparoscopic Surgery

Treatments: Drug: deep neuromuscular blockade

Study type: Observational

Funder types: Other

Identifiers

NCT04688268

B-2008/633-302

Details and patient eligibility

About

Find out the deciding factor(total body weight, corrected body weight, ideal body weight, fat-free mass, body mass index, skeletal muscle mass, body fat) of neuromuscular blocker dose for deep neuromuscular blockade.

Full description

Before the surgery, total body weight, corrected body weight, ideal body weight, fat-free mass, body mass index were measured by height and weight and skeletal muscle mass and body fat were measured by Bioelectrical impedance analysis (InbodyH20N). Find the highest correlation between the 8 factors (total body weight, corrected body weight, ideal body weight, fat-free mass, body mass index, skeletal muscle mass, body fat) and the amount of rocuronium administered to deep neuromuscular blockade.

Enrollment: 90 estimated patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients aged 20-80 and American Society of Anesthesiology Physical Grade (ASA) I-II, who undergo laparoscopic surgery for at least 2 hours under general anesthesia

Exclusion criteria

• kidney disease (GFR<60)
• allergy to study drugs
• decline participation
• side effect of propofol and remifentanil
• when anesthesia does not maintain the level of alertness (BIS) below 60 even when the anesthetic dose is increased, or when hemodynamic instability such as bradycardia and hypotension appears

Trial design

90 participants in 1 patient group

deep neuromuscular blockade

Description:

patients who underwent surgery with deep neuromuscular blockade

Treatment:

Drug: deep neuromuscular blockade