Dose of Norepinephrine and the Concentration of L-Lactate in the Rectum and Stomach in Patients With Septic Shock.

Herlev Hospital

Status: Completed

Conditions: Septic Shock

Treatments: Drug: Changing dose of norepinephrine and blood pressure

Study type: Interventional

Funder types: Other

Identifiers

NCT00197886

2004-7041-20

Details and patient eligibility

About

Norepinephrine is a drug used to increase blood pressure in patients with life-threatening infection. However, norepinephrine may limit the bloodflow to the gut, thereby causing relative lack of oxygen to the cells. This leads to increased formation of lactic acid.

This study examines whether increasing the dose of norepinephrine leads to higher concentrations of lactic acid in the rectum and stomach in patients with life-threatening infection.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Septic shock
• NE-dose > 0.1 microg/kg/min
• CI > 3.0 l/min/m2

Exclusion criteria

• Age < 18, unable to obtain informed consent from relatives
• Untreated hypertension
• Pregnancy
• Pathology in the rectum or stomach
• Limitation of therapy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind