Dose-related Effect of Aspirin on Laboratory-defined Acetylsalicylic Acid Resistance and Clinical Outcome After Coronary Stenting

Shiraz University of Medical Sciences

Status: Completed

Conditions: Coronary Stenting

Treatments: Drug: 80 mg ASA dosing; Drug: 500 mg ASA dosing

Study type: Interventional

Funder types: Other

Identifiers

NCT00966485

84-2230

Details and patient eligibility

About

The investigators prospectively studied the effect of aspirin on platelet function in 106 stable outpatients 6 months after successful percutaneous coronary angioplasty. Participants were randomized in a double-blind, double-crossover study (80 or 500 mg per day for 6 months).T

Full description

Background:

Acetylsalicylic acid (aspirin) is widely used in the secondary prevention of coronary artery disease. There is controversy regarding the prevalence of aspirin resistance in patients with coronary artery disease and the effect of dose on resistance. Our primary aims were to determine the degree of platelet responsiveness to aspirin, and to study the influence of dose on platelet inhibition and clinical outcomes after coronary stenting.

Enrollment: 106 patients

Sex: All

Ages: 40 to 67 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 6 months post stent without complication

Exclusion criteria

• subacute stent thrombosis
• unable to discontinue plavix
• dont accept to participate
• contraindication for ASA use

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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106 participants in 2 patient groups

80 mg ASA dose

Active Comparator group

Description:

6 months post stent on 80 mg ASA

Treatment:

Drug: 80 mg ASA dosing

500 mg ASA dose

Active Comparator group

Description:

6 months posr stent on ASA alone

Treatment:

Drug: 500 mg ASA dosing