Dose Response Bioavailability of Coffee and Green Tea Antioxidants in Humans

Nestlé

Status: Completed

Conditions: Healthy

Treatments: Other: Green tea; Other: Coffee

Study type: Interventional

Funder types: Industry

Identifiers

NCT01089920

09.06.MET

Details and patient eligibility

About

Coffee and green tea are 2 widely consumed beverages. Both contain polyphenol antioxidant compounds (chlorogenic acids for coffee and catechins for tea). The bioavailability of catechins is somewhat known and has been referenced in the literature. However, bioavailability data from tea infusion is non-existent, even though it reflects better how consumers drink this beverage. In addition, bioavailability of coffee chlorogenic acids is less understood and no dose response study has been reported so far in the literature. Thus, there is a great need to understand and reinforce our knowledge on the bioavailability of coffee and tea polyphenol compounds.

Enrollment: 23 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18 - 65 years, male and female
• Healthy as determined by the medical questionnaire and the medical visit
• Normal weight: BMI 18 - 25
• Coffee drinkers with an average consumption of 2-5 cups per day
• Having given informed consent

Exclusion criteria

• Intestinal or metabolic diseases / disorders such as diabetic, renal, hepatic, hypertension, pancreatic or ulcer
• Have had a gastrointestinal surgery, except appendicectomy
• Difficulty to swallow
• Have a regular consumption of medication
• Have taken antibiotic therapy within the last 6 months
• Alcohol consumption > 2 units a day
• Smokers (more than 5 cigarettes per day)
• Have given blood within the last 3 weeks
• Volunteers who cannot be expected to comply with treatment
• Currently participating or having participated in another clinical trial during the last 3 weeks

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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23 participants in 6 patient groups

High dose coffee

Experimental group

Description:

High dose of polyphenols from soluble coffee

Treatment:

Other: Coffee

Medium dose coffee

Experimental group

Description:

Medium dose of polyphenols from soluble coffee

Treatment:

Other: Coffee

Low dose coffee

Experimental group

Description:

Low dose of polyphenols from soluble coffee

Treatment:

Other: Coffee

High dose green tea

Experimental group

Description:

High dose of green tea polyphenols from infusion

Treatment:

Other: Green tea

Medium dose green tea infusion

Experimental group

Description:

Medium dose of green polyphenols from infusion

Treatment:

Other: Green tea

Low dose green tea infusion

Experimental group

Description:

low dose of polyphenols from an infusion of green tea

Treatment:

Other: Green tea