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Dose Response Effects of Inhaled Fluticasone on Airway Effects of Hypertonic-saline in Asthma (FluSAL)

University of California San Francisco (UCSF) logo

University of California San Francisco (UCSF)

Status and phase

Completed
Phase 4

Conditions

Asthma

Treatments

Drug: Fluticasone

Study type

Interventional

Funder types

Other
Industry
NIH

Identifiers

NCT00606242
5P50HL056385 (U.S. NIH Grant/Contract)
HL6788-15958-08

Details and patient eligibility

About

This study investigates the effect of a inhaled corticosteroid (fluticasone or "Flovent") on airway narrowing induced by hypertonic saline (salty water). The study hypothesis is that fluticasone will be more effective in preventing saline-induced airway narrowing than methacholine-induced narrowing.

Enrollment

44 patients

Sex

All

Ages

18 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Clinical diagnosis of asthma

Exclusion criteria

  • Habitual cigarette smoking

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

44 participants in 2 patient groups

Low dose steroid
Active Comparator group
Description:
Fluticasone, 100 mcg per day
Treatment:
Drug: Fluticasone
High dose steroid
Active Comparator group
Description:
Fluticasone, 1000 mcg per day
Treatment:
Drug: Fluticasone

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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