Dose Response Effects of Inhaled Fluticasone on Airway Effects of Hypertonic-saline in Asthma (FluSAL)

University of California San Francisco (UCSF)

Status and phase: Completed; Phase 4

Conditions: Asthma

Treatments: Drug: Fluticasone

Study type: Interventional

Funder types: Other; Industry; NIH

Identifiers

NCT00606242

5P50HL056385 (U.S. NIH Grant/Contract)

HL6788-15958-08

Details and patient eligibility

About

This study investigates the effect of a inhaled corticosteroid (fluticasone or "Flovent") on airway narrowing induced by hypertonic saline (salty water). The study hypothesis is that fluticasone will be more effective in preventing saline-induced airway narrowing than methacholine-induced narrowing.

Enrollment: 44 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of asthma

Exclusion criteria

• Habitual cigarette smoking

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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44 participants in 2 patient groups

Low dose steroid

Active Comparator group

Description:

Fluticasone, 100 mcg per day

Treatment:

Drug: Fluticasone

High dose steroid

Active Comparator group

Description:

Fluticasone, 1000 mcg per day

Treatment:

Drug: Fluticasone