Dose-response Enteral Citrulline for Normal Healthy Volunteers and Surgery Patients

Nestlé

Status: Completed

Conditions: Nutritional Deficiency

Treatments: Other: citrulline; Other: Lemonade

Study type: Interventional

Funder types: Industry

Identifiers

NCT00950976

ACSC-CIT-04-06-US

Details and patient eligibility

About

To determine the level of citrulline to produce a given amount of arginine in healthy volunteers and surgical patients. Arginine-related amino acids are expected to increase as a result of increased substrate provided by citrulline.

Enrollment: 14 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• adults, male & female, non-pregnant
• BMI 18.5-29.9

Exclusion criteria

• cancer
• HIV positive

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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14 participants in 2 patient groups, including a placebo group

Citrulline

Experimental group

Treatment:

Other: citrulline

lemonade

Placebo Comparator group

Description:

Equal volume and flavor to citrulline.

Treatment:

Other: Lemonade