Dose Response Study of a Topical Formulation of Nitroglycerin for the Treatment of Raynaud's Phenomenon

MediQuest Therapeutics

Status and phase

Completed

Phase 2

Conditions

Raynaud's Disease

Treatments

Drug: Nitroglycerin

Study type

Interventional

Funder types

Industry

Identifiers

NCT00480753

07-003

Details and patient eligibility

About

The purpose of this clinical study is to determine the response to two different dosage strengths of a topical nitroglycerin gel in patients with Raynaud's Phenomenon. Patient fingers will be monitored for changes in blood flow and skin temperature. Symptoms of pain, tingling and numbness will also be monitored.

Full description

It is the intention of this protocol to study, in a controlled manner, the response of fingers of patients with Raynaud's phenomenon to two dosage strengths of a fast acting topical formulation of Nitroglycerin, MQX-503. Patients may have moderate to severe primary Raynaud's phenomenon or Raynaud's phenomenon secondary to autoimmune diseases such as scleroderma.

Quantitative changes in blood flow in the fingers of the non-dominant hand will be measured after the clinical induction of constriction of blood vessels by exposure to local cold temperatures. Secondarily, the quantitative reduction in skin temperature recovery time and symptoms of pain, tingling and numbness associated with Raynaud's phenomenon will be evaluated using a patient hand symptom analog assessment score. The frequency and severity of adverse events associated with MQX-503 will be assessed.

Enrollment

15 estimated patients

Sex

All

Ages

18 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients with Raynaud's phenomenon
Patients who are willing to discontinue any current therapies for Raynaud's phenomenon

Exclusion criteria

The use of any medication containing nitroglycerin or known to interact with nitroglycerin
Patients with a history of migraine or other severe headaches
Open skin lesions or skin conditions in the area where medication is to be applied
Pregnant or nursing women or those wishing to become pregnant.