Dosimetric Planning Study Comparing Intensity Modulated Radiotherapy (IMRT) and 4-field Radiotherapy for Definitive Treatment of Cancer of the Cervix

Sunnybrook Health Sciences Centre

Status and phase: Completed; Early Phase 1

Conditions: Cervix Cancer

Treatments: Radiation: 4-Field Radiation Planning; Radiation: IMRT planning

Study type: Interventional

Funder types: Other

Identifiers

NCT00981552

IMRTCC

Details and patient eligibility

About

A theoretical planning study to compare the normal tissue irradiation when using intensity modulated radiotherapy (IMRT) as opposed to standard radiotherapy for the definitive treatment of cervical cancer.

Full description

Radiotherapy in combination with chemotherapy is the standard treatment of locally advanced cervix cancer, however with traditional techniques large volumes of bowel and bladder are irradiated causing short-term and long-term genito-urinary and gastro-intestinal side effects. IMRT has the potential to conform precisely to the target and spare normal tissues and reduce side effects. However because there are large dose gradients there is the potential to miss the target due to organ motion. Recent studies have documented organ motion and will be used to define the target. Approximately 60 planning scans, previously used to treat patients with cervix cancer, will be used to replan using an IMRT technique and differences in doses to tumour and normal tissues compared.

Enrollment: 55 patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

• last 60 patients treated definitively for cervical cancer at Sunnybrook Odette Cancer Centre

Exclusion criteria

• no imaging and no anatomical description of disease

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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55 participants in 1 patient group

Cervix Cancer

Other group

Description:

Patients treated with cervical cancer in 2008 at Sunnybrook Odette Cancer Centre

Treatment:

Radiation: 4-Field Radiation Planning

Radiation: IMRT planning