Dosing Iodinated Contrast Media According to Lean vs. Total Body Weight

Nova Scotia Health Authority (NSHA)

Status and phase: Completed; Phase 4

Conditions: Contrast Media Dosing

Treatments: Drug: Iohexol

Study type: Interventional

Funder types: Other

Identifiers

NCT03415997

NSHA REB 1023119

Details and patient eligibility

About

The purpose of this study is to evaluate the effect of dosing iodinated contrast media according to a patient's total body weight vs. lean body weight. Participants will be randomized into 2 groups based on contrast dosing technique, and solid organ enhancement at uniphasic abdominal CT will be measured.

Enrollment: 239 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• outpatients only
• patients scanned on modern Siemens scanners at our institution

Exclusion criteria

• self-reported history of chronic kidney, heart or liver disease
• allergy to iodinated contrast
• acute illness
• outside maximum threshold limit for weight-based contrast dosing
• pregnancy
• image degradation

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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239 participants in 2 patient groups

Total Body Weight

Active Comparator group

Treatment:

Drug: Iohexol

Lean Body Weight

Active Comparator group

Treatment:

Drug: Iohexol