Dosing of Ketorolac in the Emergency Department

University of Missouri (MU)

Status and phase: Terminated; Phase 4

Conditions: Acute Pain

Treatments: Drug: Ketorolac

Study type: Interventional

Funder types: Other

Identifiers

NCT03464461

2010856

Details and patient eligibility

About

The optimal dose of ketorolac in the Emergency Department setting is no clear. We will compare 3 doses to determine the optimal dose.

Full description

Patients from 4 groups will be treated with 3 different doses of ketorolac. The groups are 1. headache 2. abdominal pain 3. musculo-skeletal pain 4. viral syndrome. The doses will be 0, 10, 30mgs of ketorolac to clarify the placebo effect and the optimal dosage as a function of condition.

Enrollment: 289 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

> 18 y/o

Exclusion criteria

pregnant allergic other contraindication

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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289 participants in 3 patient groups, including a placebo group

0 mg

Placebo Comparator group

Description:

0 mg ketorolac - placebo

Treatment:

Drug: Ketorolac

10 mg

Active Comparator group

Description:

10 mg ketorolac - low dose ketorolac

Treatment:

Drug: Ketorolac

30 mg

Active Comparator group

Description:

30 mg ketorolac - usual dose ketorolac

Treatment:

Drug: Ketorolac