Double Carbapenem as Rescue Strategy for the Treatment of Carbapenemase-Producing Klebsiella Pneumoniae Infections

Institute of Hospitalization and Scientific Care (IRCCS)

Status: Completed

Conditions: Klebsiella Pneumonia; Carbapenem

Treatments: Other: none intervention

Study type: Observational

Funder types: Other

Identifiers

NCT03094494

UCSC14669/15 359/2015

Details and patient eligibility

About

An observational two-center case-control study exploring the clinical impact of double-carbapenem use in a population of critically il patients with severe carbapenem-resistant Klebsiella pneumoniae infection

Enrollment: 144 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

1. age ≥ 18 years;
2. ICU admission between November 2012 and December 2015;
3. documented CR-Kp invasive infection;
4. targeted antibiotic therapy lasting ≥ 72 hours

Exclusion Criteria

1. Klebsiella infection, susceptible to carbapenems
2. Duration of antimicrobial therapy less than 72 hours
3. Data not completely available from the electronically medical chart

Trial design

144 participants in 2 patient groups

Double Carbapenem Group

Description:

Patients underwent Double carbapenem treatment

Treatment:

Other: none intervention

Standard Treatment Group

Description:

Patients who were not treated with the double carbapenem

Treatment:

Other: none intervention