Double Pet Project : A Comparison Between 11C-Acetate and 11C-acetoacetate Heart and Kidney Uptake

Université de Sherbrooke

Status: Completed

Conditions: Ketoses, Metabolic

Treatments: Radiation: Observational heart and kidney on siemens TEP scan

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT05238805

2022-4540

Details and patient eligibility

About

The objective of this study is to make a comparison between 11C-acetate and 11C-Acetoacetate heart and kidney metabolism

Full description

Healthy people will have two positron emission tomography scan to perform. One, with a 11C-Acetate Tracer and the other with 11C-Acetoacetate. The results will allow to determine if both tracers are used in a similar way but the organs and see if the investigators can use the already validated analyse method for acetate to make acetoacetate analysis

Enrollment: 10 patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Aged between 18 and 55
• BMI between 18,5 and 28
• Healthy
• Normal value for blood pressure

Exclusion criteria

• Taking drugs that could influence metabolism
• Diabetes or prediabetes
• Pregnancy or lactation
• Participation in a intensive sport program
• Being on a ketogenic diet
• Any clinical abnomally in prescreen blood sample

Trial design

Primary purpose: Health Services Research

Allocation: N/A

Interventional model: Sequential Assignment

Masking: None (Open label)

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10 participants in 1 patient group

Observational heart and kidney metabolism

Other group

Description:

Participants will have a PET scan with 11C-Acetate followed by a TEP Scan with 11C-Acetoacetate all in the same day.

Treatment:

Radiation: Observational heart and kidney on siemens TEP scan