Double Pick up in Poor Prognosis Women (DUOPICK)

CRG UZ Brussel

Status and phase: Completed; Phase 4

Conditions: Fertility Disorders

Treatments: Drug: Corifollitoropin alfa (CFA)-double pick up

Study type: Interventional

Funder types: Other

Identifiers

NCT03846544

58335

Details and patient eligibility

About

The purpose of this randomized pilot study is to compare the efficacy of double oocyte retrieval vs. conventional antagonist ovarian stimulation protocol in poor prognosis patients undergoing in vitro fertilization (IVF) or intra-cytoplasmic sperm injection (ICSI).

Enrollment: 48 patients

Sex: Female

Ages: 25 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 25-40 years
• Body mass index (BMI) ≤ 35 and ≥ 19
• Antimüllerian hormone (AMH) level of ≤1.5 ng/mL or antral follicular count (AFC) of ≤6 follicles or ≤5 oocytes retrieved in a previous cycle following standard conventional ovarian stimulation.

Exclusion criteria

• Testicular sperm extraction
• History of > 3 three consecutive previous unsuccessful IVF cycles
• BMI >35 or <19
• Use of oral contraceptives <3 months before start of the treatment
• polycystic ovary syndrome (PCOS) according to the Rotterdam criteria
• Ovarian stimulation for pre-implantation genetic testing (PGT-A/M)
• Medical/social freezing
• In vitro maturation (IVM)
• History of untreated autoimmune, endocrine or metabolic disorders,
• Ovarian cystectomy or oophorectomy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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48 participants in 2 patient groups

control group

No Intervention group

double pick up group

Experimental group

Treatment:

Drug: Corifollitoropin alfa (CFA)-double pick up