Double Trigger in Patients With Low Number of Oocytes Retrieved Per Number of Preovulatory Follicles

Riyadh Fertility and Reproductive Health center

Status and phase: Unknown; Phase 2

Conditions: Infertility, Female

Treatments: Drug: HCG trigger; Drug: Double trigger

Study type: Interventional

Funder types: Other

Identifiers

NCT04407065

Double trigger/more oocytes

Details and patient eligibility

About

The aim of this randomized controlled trial is to determine whether co-administration of GnRH agonist and hCG for final oocyte maturation ( 40 and 34 h prior to oocyte retrieval , respectively) can increase the oocytes yield in patients with history of poor oocytes yield, despite normal response to COH, due to low (<50%) number of oocytes retrieved per number of follicles > 14 mm in diameter on day of hCG administration

Enrollment: 56 estimated patients

Sex: Female

Ages: 18 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with history of poor oocytes yield in previous IVF attempt, despite normal response to COH, due to low (<50%) number of oocytes retrieved per number of follicles > 14 mm in diameter on day of hCG administration
• Patients with 6 to 15 mature follicles on the day oocyte trigger in the current IVF-ET attempt

Exclusion criteria

• Endometriosis
• PCOS

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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56 participants in 2 patient groups

Double trigger

Experimental group

Description:

GnRH-agonist and HCG are used to trigger ovulation

Treatment:

Drug: Double trigger

HCG

Active Comparator group

Description:

HCG is used to trigger ovulation

Treatment:

Drug: HCG trigger