Downstaging Prediction Model for HCC

Beijing Tsinghua Chang Gung Hospital

Status: Not yet enrolling

Conditions: HCC - Hepatocellular Carcinoma

Study type: Observational

Funder types: Other

Identifiers

NCT07058649

25288-0-02

Details and patient eligibility

About

This study is a real-world, single-center study that collects imaging and clinical data from patients with HCC who are downstaged beyond the UCSF criteria.

Full description

This study is a real-world, single-center study that collects imaging and clinical data from patients with HCC who are downstaged beyond the UCSF criteria. It constructs a predictive model for downstaging treatment of liver cancer beyond the UCSF standards and completes external validation. This model will assist in clinical decision-making for the downstaging treatment of liver cancer beyond the UCSF criteria. Further downstaging methods are stratified to guide the selection of individualized downstaging treatment options for liver cancer beyond the UCSF standards.

Enrollment: 369 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• (A) Adult patients with HCC over the age of 18 (clinically diagnosed or pathologically diagnosed); (B) Liver function Child-Pugh score of Class A, or Class B with a score of 7 or below (including 7); (C) A single solid tumor with a diameter of ≥6.5 cm; three or more lesions, among which at least one tumor has a diameter >4.5 cm or the sum of the diameters is ≥8 cm; invasion of major blood vessels regardless of tumor size and number.

Exclusion criteria

• (A) Presence of distant metastasis outside the liver; (B) General performance status score (PS score) greater than 2 points.

Trial design

369 participants in 1 patient group

Successful downstaging

Description:

Failure downstaging