DPBRN Retrospective Cohort Study of Osteonecrosis of the Jaw

Dental Practice-Based Research Network

Status: Completed

Conditions: Osteonecrosis of the Jaw

Study type: Observational

Funder types: Other; NETWORK; NIH

Identifiers

NCT01201330

U01DE016747 (U.S. NIH Grant/Contract)

106030

Details and patient eligibility

About

The purpose of this study was to determine the prevalence of ONJ in the patient population of 2 large HMOs and study the risk factors associated with the development of this condition.

Full description

The electronic database from Kaiser Permanente and HealthParnters of Minnesota were used to identify all ONJ cases that occured between 1994 and 2006 and then demographic, social and medical risk factors possibly associated with the disease were abstracted and analyzed.

Enrollment: 572,606 patients

Sex: All

Ages: 41+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• ONJ sufferers and control biphosphonate users older than 40, of any gender, race and ethnic origin

Trial design

572,606 participants in 2 patient groups

ONJ sufferers

Description:

history of jaw osteonecrosis

Bisphosphonate exposure

Description:

patients with exposure to bisphosphonates