DPP4 Inhibitor and Coronary Atherosclerosis in Patients Receiving Insulin Therapy

The Catholic University of Korea

Status: Completed

Conditions: Diabetes Mellitus

Treatments: Drug: No DPP4-inhibitor; Drug: DPP4-inhibitor

Study type: Observational

Funder types: Other

Identifiers

NCT04825795

XC21WIDI0044

Details and patient eligibility

About

The study aim is to evaluate whether DPP4-inhibitor could reduce coronary atherosclerosis assessed by CT scan in patients receiving insulin for diabetes mellitus. In this retrospective study, changes in obstructive coronary artery disease prevalence and coronary calcium burden between two coronary CT scans will be compared in patients with and without receiving DPP4-inhibitor.

Full description

This is a retrospective study using medical records in two hospitals affiliated to the Catholic University of Korea. Patients with diabetes mellitus who received insulin are retrospectively enrolled. Among those, only patients who underwent coronary CT scan for more than two times will be included. Included patients will be classified into DPP4-inhibitor group and no DPP4-inhibitor group according to the prescribed medication. The changes in obstructive coronary artery disease prevalence and coronary calcium score per one year will be compared between the two groups.

Enrollment: 4,007 patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diabetes mellitus
• Receiving chronic insulin therapy (prescription of insulin pen)
• Who underwent more than 2 times of coronary CT scan

Exclusion criteria

• Age <18

Trial design

4,007 participants in 2 patient groups

DPP4-inhibitor

Description:

Patients who were prescribed DPP4-inhibitor during the period between two coronary CT scan.

Treatment:

Drug: DPP4-inhibitor

No DPP4-inhibitor

Description:

Patients who were not prescribed DPP4-inhibitor during the period between two coronary CT scan.

Treatment:

Drug: No DPP4-inhibitor