Drainage of Tuberculous Pleural Effusions

Taipei Medical University

Status

Completed

Conditions

Tuberculous Pleurisy

Treatments

Procedure: Pigtail drainage

Study type

Interventional

Funder types

Other

Identifiers

NCT00524147

TMU92-AE1-B36

Details and patient eligibility

About

Tuberculous (TB) pleurisy can cause clinical symptoms and pleural fibrosis with resultant residual pleural thickening (RPT). Therapeutic thoracentesis or initial complete drainage in addition to anti-TB drugs have been tried to rapidly relieve dyspnea caused by effusion and to decrease the occurrence of RPT. However, contradictory results are reported without clear reasons. The researchers' hypothesis is that, in addition to anti-TB medications, early effective evacuation of inflammatory exudates with or without fibrinolytic agents may hasten resolution of pleural effusion, reduce the occurrence of RPT and finally improve long-term functional outcome in patients with TB pleurisy.

Enrollment

64 patients

Sex

All

Ages

16+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Diagnosis of tuberculous pleurisy

Exclusion criteria

History of invasive procedures directed into the pleural cavity
Recent severe trauma, hemorrhage, or stroke; bleeding disorder or anticoagulant therapy
Use of streptokinase in the previous 2 years
Lack of clinical symptoms caused by effusions