Dreaming and EEG Changes During Anaesthesia Maintained With Propofol or Desflurane

Melbourne Health

Status and phase: Completed; Phase 4

Conditions: Anaesthesia

Treatments: Drug: Propofol; Drug: desflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT00446212

2006.125

Details and patient eligibility

About

We hypothesise that patients who receive propofol for maintenance of anaesthesia will report dreaming more often when they emerge from anaesthesia than patients who receive desflurane for maintenance of anaesthesia.

Full description

Patients commonly report that they have been dreaming when they emerge from anaesthesia. Data from observational studies and small randomised trials suggests that reports of dreaming are more commonly made after anaesthesia maintained with propofol than anaesthesia maintained with inhaled anaesthetic agents. We propose to randomise 300 healthy patients to receive a standardised general anaesthetic for surgery that includes either propofol or desflurane for maintenance. We will measure the raw and processed electroencephalogram during and after anaesthesia and interview patients about dreaming as soon as they emerge from anaesthesia.

Enrollment: 300 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Male and female patients
• Age between 18 and 50 years
• Presenting for elective surgery under general anaesthesia

Exclusion criteria

• Inadequate English language comprehension
• Major drug abuse problem

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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300 participants in 2 patient groups

1

Active Comparator group

Description:

Propofol based anaesthetic maintenance with propofol effect-site steered target-controlled infusion, in addition to fentanyl and non-opioid analgesics

Treatment:

Drug: Propofol

2

Active Comparator group

Description:

Desflurane based anaesthetic maintenance with manually controlled administration in 100% oxygen in addition to fentanyl and non-opioid analgesics

Treatment:

Drug: desflurane