Dried Plums for Bone Health in Older Postmenopausal Women

San Diego State University

Status: Completed

Conditions: Bone Diseases, Metabolic

Treatments: Other: Dried Plum

Study type: Interventional

Funder types: Other

Identifiers

NCT02325895

57114A

Details and patient eligibility

About

The objective of the investigators current study was to examine whether 50 g dried plum would be as effective as 100 g dried plum in reversing bone loss in osteopenic older postmenopausal women.

Full description

Forty-five randomly assigned into one of three treatment groups: 1) 50g dried plum; 2) 100g dried plum; and 3) control (0g dried plum). All groups received 500mg calcium and 400 IU vitamin D as a daily supplement. Blood samples were collected at baseline, 3 and 6 months to assess biomarkers of bone turnover. Physical activity recall and 3-day food records were obtained at baseline, 3 and 6 months to examine physical activity and dietary confounders as potential covariates

Enrollment: 48 patients

Sex: Female

Ages: 65 to 79 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMD t-score of L1-L4 between -1 to -2.5 standard deviation of the mean
• Age 65 to 79

Exclusion criteria

• BMD t-score at any site fell below 2.5 standard deviation of the mean
• Subjects treated with calcitonin, bisphosphonates, raloxifene and/or anabolic agents such as parathyroid hormone and growth hormone, or steroids within three months before the start of the study
• Metabolic bone disease, renal disease, cancer, CVD, diabetes mellitus, respiratory disease, gastrointestinal disease, liver disease or other chronic diseases, heavy smoking (more than twenty cigarettes/day) and current use of any prescription medications known to alter bone and calcium metabolism
• Regularly consumed dried plum or prune juice were not included in the study.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: None (Open label)

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48 participants in 3 patient groups

Control (0 g Dried plum/day)

No Intervention group

Description:

Participants only received 400IU of vitamin D and 500mg of calcium daily for 6 months.

50 g Dried plum/day

Experimental group

Description:

Participants received 400IU of vitamin D and 500mg of calcium and 50g of dried plum daily for 6 months.

Treatment:

Other: Dried Plum

100 g Dried plum/day

Experimental group

Description:

Participants received 400IU of vitamin D and 500mg of calcium and 100g of dried plum daily for 6 months.

Treatment:

Other: Dried Plum