Drinking Water PFAS, Pregnancy Outcome and Maternal Morbidity

Karolinska Institute

Status: Completed

Conditions: Birth Weight; Preeclampsia; Diabetes, Gestational; Large for Gestational Age at Delivery (Macrosomia); Small for Gestational Age at Delivery; Hypertension in Pregnancy; Congenital Malformation

Treatments: Other: Per- and polyfluoroalkyl substances (PFAS)

Study type: Observational

Funder types: Other

Identifiers

NCT05810545

EXP-21-CV8301

2022-00980 (Other Grant/Funding Number)

Details and patient eligibility

About

The aim of the project is to assess the association between exposure to per- and polyfluoroalkyl substances (PFAS) via drinking water in pregnancy and birth outcomes (i.e. growth retardation, premature birth, and congenital developmental defects) and maternal morbidity (gestational hypertension, diabetes and preeclampsia) in a prospective population-wide register study.

Enrollment: 256,659 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Pregnant women residing in Swedish localities with a population exceeding 10,000 inhabitants and giving birth during 2012-2018

Exclusion criteria

• Lack of data of PFAS levels in municipal drinking water (entire localities excluded)
• Mothers not living in the study area consistently between first trimester and four years prior to birth