Drip-infusion of Remifentanil for RIH

Tri-Service General Hospital

Status: Completed

Conditions: Hyperalgesia

Treatments: Drug: remifentanil

Study type: Observational

Funder types: Other

Identifiers

NCT04387097

TSGHIRB No: 2-108-05-135

Details and patient eligibility

About

The development of remifentanil-induced hyperalgesia (RIH) is an unpleasant experience for surgical patients. An alternative management, gradual withdrawal of remifentanil was effective in prevention of RIH. The investigators designed a simple modality to assess if under withdrawal of remifentanil and further drip-infusion of remifentanil immediately after extubation affected postoperative pain score, the requirement of rescue analgesics, and adverse effects.

Full description

In clinical practice, the gradual withdrawal of remifentanil during surgery is unsatisfied. Thus, the investigators conducted a simple modality in a single center retrospective cohort study to assess how under baseline gradual withdrawal of remifentanil and further drip infusion of remifentanil immediately after extubation affected postoperative pain score and use of analgesics.

Enrollment: 559 patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists (ASA) score of I-III patients receiving total intravenous anesthesia

Exclusion criteria

• The use of inhalation agents or propofol combined with inhalation anesthesia
• Pregnancy
• Previous substance abuse
• Known allergies to opioids, propofol or any drugs used in the study
• History of neuropsychiatric disorder
• Age < 20 years or > 80 years

Trial design

559 participants in 2 patient groups

gradual withdrawal following by drip-infusion of remifentanil

Description:

In the end of the surgery, gradual withdrawal of remifentanil was prescribed until the endotracheal tube was extubated. Following by drip-infusion of remifentanil for 30 minutes was administered immediately after tracheal extubation.

Treatment:

Drug: remifentanil

gradual withdrawal of remifentanil

Description:

In the end of the surgery, gradual withdrawal of remifentanil was prescribed until the endotracheal tube was extubated.