Driving Pressure and Postoperative Pulmonary Complications

Samsung Medical Center

Status: Completed

Conditions: Driving Pressure; One-Lung Ventilation; Postoperative Respiratory Complications

Treatments: Other: Driving Pressure Limited Ventilation

Study type: Interventional

Funder types: Other

Identifiers

NCT02851238

SMC 2016-05-107-003

Details and patient eligibility

About

This study aims to prove that driving pressure limited ventilation is superior in preventing postoperative pulmonary complications to existing protective ventilation.

Enrollment: 312 patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults greater than or equal to 19 years
• Patient who undergoes one-lung ventilation for thoracic surgery

Exclusion criteria

• The American Society of Anesthesiologists (ASA) Physical Status classification greater than or equal to 4
• Patient who is contraindicated with application of positive end expiratory pressure
• Patient who rejects being enrolled in the study

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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312 participants in 2 patient groups

Protective Ventilation

No Intervention group

Description:

The control arm receives existing conventional protective ventilation with tidal volume of 6mL/kg of ideal body weight and positive end expiratory ventilation of 5cmH2O during one-lung ventilation

Driving Pressure Limited Ventilation

Experimental group

Description:

The intervention arm receives driving pressure limited ventilation during one-lung ventilation

Treatment:

Other: Driving Pressure Limited Ventilation