Driving Pressure-guided PEEP Titration in Robot-assisted Laparoscopic Surgeries

Seoul National University

Status: Completed

Conditions: Atelectasis, Postoperative Pulmonary

Treatments: Procedure: Titrated PEEP based on driving pressure; Procedure: Conventional PEEP

Study type: Interventional

Funder types: Other

Identifiers

NCT04327193

SYoon_DP_RALP

Details and patient eligibility

About

The purpose of this study is to investigate the effect of driving-pressure guided positive end-expiratory pressure (PEEP) titration.

Enrollment: 66 patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing robot-assisted laparoscopic prostatectomy with Trendelenburg position

Exclusion criteria

• American Society of Anesthesiologists physical status IV or more
• Severe cardiovascular disease
• Severe chronic obstructive pulmonary disease, emphysema
• History of pneumothorax, bullae
• History of lung resection surgery
• Conversion to laparotomy
• Refusal to participate

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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66 participants in 2 patient groups

Driving pressure

Experimental group

Description:

The selected PEEP which makes the driving pressure lowest is applied during the operation.

Treatment:

Procedure: Titrated PEEP based on driving pressure

Conventional

Active Comparator group

Description:

Conventional PEEP (5cmH2O) is applied.

Treatment:

Procedure: Conventional PEEP