Droperidol Versus Metoclopramide + Diphenhydramine for the Treatment of Primary Headaches
Status
Conditions
Treatments
Details and patient eligibility
About
The purpose of this study is to determine if droperidol is equally as effective as metoclopramide for treatment of primary headaches in the Emergency Department.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- 18 years old to 65 years old, diagnosis of primary headache
Exclusion criteria
- Allergy to study medications, pregnant, breast-feeding, prisoners, non-english speaking, not eligible to receive droperidol based on ED protocol (see below), patients in whom head trauma, infection, vascular disorders, and disorders of facial or cranial structures are suspected
ED Droperidol Protocol
Droperidol must NOT be used in patients with any of the following:
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Known or suspected QT prolongation, including congenital long QT syndrome
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Cardiac Disease [cardiomyopathy, congestive heart failure, hypertension, ischemic heart disease, myocardial infarction, bradycardia (< 50 bpm)]
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History of the following:
- Renal failure
- Cerebrovascular disease
- Diabetes or hypoglycemia
- Alcoholism/alcohol abuse
- Pituitary insufficiency
- Hypothyroidism
- Hypothermia
- Anorexia
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Advanced age (>65 yrs)
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Use of the following medications: digoxin, benzodiazepine, diuretics, IV opiates, or other medications known to prolong the QTc interval.
Trial design
Primary purpose
Allocation
Interventional model
Masking
19 participants in 2 patient groups
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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