Drug Delivery Devices for Osteomyelitis

Yulin Orthopedics Hospital of Chinese and Western Medicine

Status: Completed

Conditions: Osteomyelitis

Treatments: Device: antibiotic-loaded polymethyl methacrylate; Device: antibiotic-loaded calcium sulfate; Drug: Vancomycin

Study type: Observational

Funder types: Other

Identifiers

NCT02968693

20150801c

Details and patient eligibility

About

Fifty-one patients suffering from chronic post-traumatic or postoperative osteomyelitis of the lower extremities were included in the retrospective investigation. The patients were assigned to the study group of the combination therapy with antibiotic-loaded calcium sulfate and antibiotic-loaded PMMA or the control group of the antibiotic-loaded PMMA. Hematological parameters, eradication of infection, rate of infection recurrence and reoperation rate were evaluated during the follow-up.

Enrollment: 51 patients

Sex: All

Ages: 15 to 68 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• The retrospective study included patients with chronic post-traumatic or postoperative osteomyelitis and excluded patients suffering from hematogenous osteomyelitis or acute post-traumatic or postoperative osteomyelitis.

Exclusion criteria

• Other kinds of osteomyelitis.

Trial design

51 participants in 2 patient groups

combination therapy group

Description:

antibiotic-loaded calcium sulfate and antibiotic-loaded polymethyl methacrylate (PMMA) and Vancomycin

Treatment:

Device: antibiotic-loaded calcium sulfate

Drug: Vancomycin

Device: antibiotic-loaded polymethyl methacrylate

PMMA group

Description:

antibiotic-loaded polymethyl methacrylate and Vancomycin

Treatment:

Drug: Vancomycin

Device: antibiotic-loaded polymethyl methacrylate